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Jews and Genetic Disorders

Credit: ‘EM Unit, UCL Medical School, Royal Free Campus’. Wellcome Images
Introduction
Victoria Gray, a Black American woman now in her mid-thirties, was just three months old when she suffered her first painful bout with sickle cell disease (SCD), a debilitating genetic blood disorder. SCD is caused by a mutation of the hemoglobin-beta (HBB) gene in chromosome 11 that alters the shape of normally flexible, round red blood cells into rigid, crescent shaped cells. When it does, the flow of red blood cells that usually deliver oxygen to bodily tissues is restricted resulting in limited oxygen delivery to tissues and associated severe pain. Until recently, treatment consisted primarily of strong pain relief medication and, also, frequent blood transfusions. SCD affects about 100,000 people in the United States, more than 90% of whom are African-American or non-Hispanic Black, and millions more worldwide.
In 2019, Ms. Gray became the first patient with any form of genetic disease to be treated by gene-editing technology known as CRISPR which modified blood cells taken from her bone marrow for subsequent infusion back into her body. Two years later, she was not only pain free, but doing well enough to no longer be part of the landmark study for which she volunteered, although she will continue to be followed for fifteen more years in order to check the long-term safety and efficacy of her treatment.
read moreJews, Judaism and Genetically Modified Crops
Credit: USDA
Genetically modified (“GM”) crops are plant products which have been genetically altered for certain traits. Such traits include resistance to viruses, bacteria, fungi, nematodes, insects, herbicides and drought, as well as aspects of product quality like improved yield, nutritional value and longer shelf life. (See here and here.)
The characterization is somewhat of a misnomer. Modification of biological organisms is not a new process. It has been occurring in nature for billions of years. Indeed, the natural selection of some traits over others is the driving force of biological evolution, the process by which a species over time secures a competitive advantage in its environment. Today, though, the label of GM foods is meant to identify those products that have been modified or engineered by human means.
And yet, the intervention of humans in an otherwise natural process is not new either. Humans have been actively engaged in plant breeding for up to ten thousand years. An Assyrian relief, dated to 870 BCE, illustrates pollination of date palms by man.
Similarly, the Torah tells of Jacob manipulating his flocks of goats and lambs so that he would increase his herd with the fittest among them. (See Gen. 30:31-31:13.)That the author ambiguously attributed Jacob’s success to both magical sticks and God’s miraculous power is irrelevant, for present purposes. What is important is that the story is testament to the reality that at least since the text was written some twenty-five centuries ago, humans have recognized the desirability of and have sought to guide the alteration of existing species in ways thought beneficial. This guided intervention has produced a host of useful and now common food products, but it is, or was, slow, unpredictable, unreliable, costly and inefficient. read more
Ginger Jews
Last year, about two hundred red haired Israeli Jews gathered for a conference at Kibbutz Gezer in Israel. While that is a nice size group, there were, apparently, many hundreds who were interested in attending, but unable to do so. Those who attended the conference shared stories, sang a popular children’s song called “I am a Redhead,” and reportedly had a good time. Gezer, by the way, is Hebrew for carrot.
And then there is Stav Shaffir, the not even thirty year old Member of the Knesset whose hair is vibrant red. Stav, by the way, is Hebrew for Autumn.
There is even Hebrew slang for redheads: gingi (Jeenji) for a male and gingit (Jeenjit) for a female, both Hebraicized corruptions of the English ginger.
What’s with Jews and red hair? read more