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When Judaism Meets Science
Welcome!
Welcome to a discussion about Judaism and science, about fact, fiction, and faith. Now in its twelfth year, this site has already explored a wide range of issues, from archeology to zygotes and from adam (mankind) to t’filah (prayer). And we have done so unsponsored and unencumbered by any particular denomination.
Along the way, we have encountered some interesting ideas, met some fascinating people and even gained some new perspectives. And our journey has really just begun. All who are interested in a thoughtful, respectful and constructive dialogue are invited to participate.
Judaism and the Ethical Challenges of Gene Editing
Credit: National Inst. of Health
Introduction
The manipulation of our genes is a new and rapidly developing process for addressing genetic disorders of the kind we have discussed in “Jews and Genetic Disorders.” What if medical science could develop safe and effective procedures to eliminate variant (or other unwanted) genes from our bodies and replace them with normal (or other more desired, if not objectively better) genes? Engaging with gene-altering technology raises a host of practical questions each and all of which also invoke ethical considerations. A Venn diagram which included areas at least for medical, political, economic, and ethical areas of concern might illustrate the general complexity of the matter, but we need more than a picture to get to the nits and grits of the subject.
Jews may have a unique perspective from which to begin our investigation. We have been talking about health matters for over 2,500 years, and have, based on our religious texts and traditions, and our experience, developed a useful orientation, or, perhaps better, a useful conversation for considering the challenges of human gene editing.
As we have discussed elsewhere with respect to vaccinations, the origin of any Jewish ethical approach has its beginnings at the very start of the Jewish Peoples’ origin story. We don’t have to go all the way back to the pre-creation state of chaos, just to the first report of the creation of humankind. There we are told that humans were created by a Supreme Being and made b’tzelem Elohim, in God’s own image. (Gen. 1:27.) Rabbi Danny Nevins, of the Jewish Theological Seminary, acknowledges that this phrase is ambiguous. Moving beyond any notion of physical similarity, though, Rabbi Nevins holds that it at least “implies that humanity has God-like qualities and therefore great responsibilities.”
read moreJews and Genetic Disorders
Credit: ‘EM Unit, UCL Medical School, Royal Free Campus’. Wellcome Images
Introduction
Victoria Gray, a Black American woman now in her mid-thirties, was just three months old when she suffered her first painful bout with sickle cell disease (SCD), a debilitating genetic blood disorder. SCD is caused by a mutation of the hemoglobin-beta (HBB) gene in chromosome 11 that alters the shape of normally flexible, round red blood cells into rigid, crescent shaped cells. When it does, the flow of red blood cells that usually deliver oxygen to bodily tissues is restricted resulting in limited oxygen delivery to tissues and associated severe pain. Until recently, treatment consisted primarily of strong pain relief medication and, also, frequent blood transfusions. SCD affects about 100,000 people in the United States, more than 90% of whom are African-American or non-Hispanic Black, and millions more worldwide.
In 2019, Ms. Gray became the first patient with any form of genetic disease to be treated by gene-editing technology known as CRISPR which modified blood cells taken from her bone marrow for subsequent infusion back into her body. Two years later, she was not only pain free, but doing well enough to no longer be part of the landmark study for which she volunteered, although she will continue to be followed for fifteen more years in order to check the long-term safety and efficacy of her treatment.
read moreThe Metals of the Hebrew Bible: Gold and Silver
Of the ninety-two elements naturally occurring on Earth, the Hebrew Bible (the “Tanach”) mentions only six. The two most abundant elements in the Earth’s crust, by mass, are oxygen and silicon. Even though together they account for just over three-quarters of the mass of the crust, the Tanach says nothing about them. Aluminum is the next most common element, accounting for about eight percent of the mass of the crust, but it, too, is unknown, or at least unmentioned, by the authors of the Tanach.
The elements that the Hebrew Bible does identify, ordered by the frequency of mention, are gold, silver, copper, iron, tin, and lead. Uniquely, in the Book of Numbers (at 31:22), they are mentioned together and in that order as metals that can be purified by fire. Sometimes they are mentioned elsewhere in different combinations and various orders. Mostly, though, they are mentioned separately , although gold and silver are often cited jointly.
Gold, zahav in Hebrew, is the most frequently mentioned metal, being identified almost 400 times, according to one concordance. Silver, or kesef, is mentioned the next most frequently, almost 300 times. Counting copper is a bit problematic as the Hebrew word for copper is nechoshet, but that word is also translated sometimes as bronze and sometimes as brass, both of which are alloys of copper. Despite the frequency of their mention, gold, silver, and copper together account for less than 0.007% of the Earth’s crust. Still, the Torah mentions these three metals as important, for instance in the adornment of the Tabernacle. (See, e.g., Ex. 31:3-5.)
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